Ketamine: A Promising Treatment for Complex Regional Pain Syndrome (CRPS)

Complex Regional Pain Syndrome (CRPS) is a chronic pain condition that typically affects the limbs after an injury or surgery. Characterized by severe, persistent pain, CRPS can significantly impact a person’s quality of life. Traditional treatments often fall short, leaving patients in desperate need of effective relief. Recent studies suggest that ketamine, an anesthetic known for its rapid antidepressant effects, may offer hope for those suffering from CRPS.

Understanding CRPS

CRPS is believed to result from a malfunction in the peripheral and central nervous systems, leading to prolonged or excessive pain signals. Symptoms include intense pain, swelling, changes in skin color and temperature, and sensitivity to touch. The condition can be debilitating, making even simple daily activities challenging.

How Ketamine Helps with CRPS

Ketamine works by blocking NMDA (N-methyl-D-aspartate) receptors in the brain, which are involved in pain transmission and central sensitization, a key factor in chronic pain conditions like CRPS. By inhibiting these receptors, ketamine can reduce the abnormal pain signaling associated with CRPS.

Study Examples and Evidence

  1. Efficacy in Reducing Pain: A study published in *Pain Medicine* examined the effects of intravenous ketamine infusions in CRPS patients. The results showed significant pain reduction in most participants, with some experiencing relief lasting for weeks to months after treatment.
  2. Improved Quality of Life: Another study in *The Clinical Journal of Pain* reported that ketamine not only reduced pain intensity but also improved patients’ overall quality of life. Participants noted better sleep, mood, and physical functioning following ketamine therapy.
  3. Long-Term Benefits: Research published in *Anesthesia & Analgesia* highlighted the potential long-term benefits of ketamine for CRPS. The study found that repeated ketamine infusions provided sustained pain relief for several months, suggesting a cumulative effect with ongoing treatments.

Our Pain Protocol at Quad Cities Ketamine & Wellness Clinic

At Quad Cities Ketamine & Wellness Clinic, we offer a specialized pain protocol designed to maximize the benefits of ketamine therapy for CRPS. Our protocol involves a series of 5 consecutive infusions, each lasting 3-4 hours, followed by an hour-long recovery period. This intensive approach ensures that patients receive the optimal dosage and duration needed for significant pain relief.

Is Ketamine Therapy Right for You?

While ketamine therapy has shown promise in treating CRPS, it is essential to consult with a healthcare professional to determine if it is the right option for you. Our team at Quad Cities Ketamine & Wellness Clinic is dedicated to helping you make an informed decision. We provide comprehensive evaluations and personalized treatment plans to address your specific needs.


Ketamine therapy represents a groundbreaking approach to managing the debilitating pain associated with CRPS. If you or a loved one is struggling with this condition and have found limited relief from traditional treatments, ketamine therapy might be the solution you’ve been seeking. Contact Quad Cities Ketamine & Wellness Clinic today to learn more about how ketamine can help you reclaim your life from the grips of chronic pain.

Taking steps towards effective pain management can significantly enhance your quality of life. Let us support you on your journey to better health and wellness with our expert and compassionate care.


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